13 October, 2008

Staphyloccal Scalded Skin Syndrome in mouse

Photo: SSSS in ddY mouse. Upper 2 mouses were subcutaneously injected
---------with different doses of the Staphylococcus aureus which were cultured 
---------from the SSSS patient. Lower one was the control(St. aureus, Cowan I )
----------(provided by Dr Hisanori Konishi, Department of Bacteriology, 
-----------Yamaguchi University School of Medicine)

The disease is caused by strains of Staphylococcal aureus, which
produce exofoliative toxins(A or B), which absorbed, cause the
separation of cells within epidermis.

The Staphylococcal aureus, which isolated from the baby with
this disease, was cultured and then Mouse(ddY) was inoculated
subcutaneously with the its Staphylococci. A positive Nikolsky
sign(peeling of skin) indicate the epidermolytic activity or
presence of exfoliative toxins.

Any questions: write to Keiji Hagiwara, MD
------------------------------  keijihagiwara@gmail.com