30 December, 2008

Roseola (= Exanthema subitum)

---------------------------------------
Roseola= Exanthema subitum
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This disease may suffer 2/3 of the Japanese child.

Etiology: human herpes virus 6.
|||||||||Age: 3 months to 3 years (frequently 7 months~ 1.5 years)
Course:
||||||||||||||||||1) high fever(39~40℃) last for 3~5 days.
||||||||||||||||||||||| but child do not seem very sick.
||||||||||||||||||2) no cough, no runny nose( frequently, loose or watery stool) .
||||||||||||||||||3) a fever subside, then a red rash appear in body.
||||||||||||||||||||||||The type of rash is variable; Rubella like~Measles like~
||||||||||||||||||||||||or diffuse pink rash. Rash disappear in several days.

Complication:
|||||||||||||||1) febrile convulsion
|||||||||||||||2) encephalitis (rare)

||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||Fig : a fever chart of Roseola(1-year-old infant).

||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||December 25th; fever started at the night.
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||no cough & running nose.
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 26th;. high fever(40.5 ℃) in the noon.
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||27th; fever subsided to 38℃.at night,
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||slight rash appeared.


Any questions: write to Keiji Hagiwara, MD.

28 December, 2008

My publications

----------------------------------------------------------------------------------------------
Grants:

1) 1981. a grant-In-Aid for Scientific Research for the Ministry
of Education, Science & Culture of Japan
(Study on protein synthesis of Molar Trophoblasts)

2) 1984. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Study on action of IgA protease from intestinal bacteria on secretory IgA)
3) 1985. a grant-In-Aid from Naito Memorial Medical Foundation with
Kobayashi K. (A separation procedure of parental secretory IgA by a lectin
and development of a method for elimination of IgA in human gamma-
globulin)

4) 1986. a grant-In-Aid from MORINAGA MILK Co. LTD.
with Kobayashi K. (Studies of anti-protease activity of pathogenic
bacterias present in human sIgA and serum IgA, IgG)

5) 1987. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Biological roles of IgA protease-neutralizing antibody in mucosal defences)

6) 1989. a grant-In-Aid for Scientific Research for the Ministry of Education,
Science & Culture of Japan.
(Anti-bacterial antibody activity of IgA subclass in normal subjects)
http://kaken.nii.ac.jp/en/p/63570440/1989/6/en
7) 1990. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A survey of acute neurological diseases in childhood in Yamaguchi
Prefecture)
8) 1991. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children)
9) 1992. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations, the Ministry of Health &Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children).
(A survey of familial transmission of whooping cough in Yamaguchi
Prefecture) .
(A survey of mother's knowledge of Measles and Measles Vaccine)

10) 1997-8. a grant-In-Aid for Scientific Research for the Ministry of
Education, Science & Culture of Japan.
(Study on rapid diagnosis of sepsis in childhood by PCR method)
平成9年度−10年度 文部省科学研究(一般研究C,500万)
 研究課題:敗血症の迅速診断に関する研究.
 研究代表者:萩原啓二
 分担者:山口医療技術短期大学部(塚原正人,山城安啓)
http://kaken.nii.ac.jp/en/r/50127776
------------------------------------------------------------------------------------------

Publications:
Omit the Japanese publication.

(Journal)
1) Monozygotic twins discordant for Rubinstein-Taybi syndrome.
(Kajii T, Hagiwara K, Tsukahara M, Nakajima H, Fukuda Y)

2) Dispermic origin of XY hydatidiform moles.
(Ohama K, kajii T, Okamoto E, Fukuda Y, Imaizumi K, Tsukahara M,
Kobayashi K, Hagiwara K,)

3) Esterase D polymorphism in hydatidiform mole.
(Hagiwara K, Kobayashi K, Kajii T)
Jpn. J. Hum. Genet. 27(2)180,1982.

4) Pfeiffer syndrome or Saethre-Chotzen syndrome?
(Tsukahara M, Hagiwara K, Kajii T)

5) J chain -like component in 18-S immunoglobulin of the skate,
Raja kenojei, a cartilaginous fish.
(Hagiwara K, Kobayashi K, Kajii T, Tomonaga S)
Molec. Immunol. 22 :775- 778, 1985.(July)

6) Isolation and characterization of immunoglobulin of hagfish,
Eptatretus burgeri, a primitive vertebrae.
(Kobayashi K, Tomonaga S, Hagiwara K)
Molec. Immunol. 22 : 1091- 1097, 1985.(Sep)

7) Studies of immunoglobulin and immunoglobulin-forming cells in
Heterodontus japonics, a cartilaginous fish.
(Tomonaga S, Kobayashi K, Hagiwara K, Sasaki K, Sezaki K)
Devel. Comparat .Immunol. 9 : 617- 626, 1985.

8) Purification and characterization of esterase D1 and D2 from human
erythrocytes: Evidence that they are monomers.
( Matsuo K, Kobayashi K, Hagiwara K, Kajii T)
Eur. J. Biochem. 153 : 217-222, 1985.

9) Double precipitin arcs of IgA myeloma sera on immuno-electrophoresis:
Origin and suggestion of IgA2,2m(2) allotype.
(Kobayashi K, Hagiwara K, Vaerman J-P, Kajii T)
Immunol. Invest. 14 :455- 468, 1985.

10) Serum proteins in vesicular fluid of hydatidiform moles: A lack of
selectivity of molar trophoblast in the transfer of maternal serum proteins.
(Hagiwara K, Kobayashi K, Kajii T)

11) Gut-associated lymphoid tissue in Elasmobranchs.
(Tomonaga S, Kobayashi K, Hagiwara K, Yamaguchi K,Awaya K)
Zool. Sci. 3 :453- 458, 1986.

12) Jacalin, a jackfruit lectin, precipitate IgA1 but not IgA2 subclass on
gel diffusion reaction.
(Kondoh H, Kobayashi K, Hagiwara K, Kajii T)

13) Complexes of albumin and a1-antitrypsin with Fc fragment of IgA
monomer are disulfide bond to penultimate C-terminal cysteine in
the Ca3 domain.
(Vaerman J-P, Hagiwara K, Kobayashi K, Rits M)
Immunol. Letters 15: 67- 72, 1987.

14) Normal serum IgA as well as secretory IgA is resistance to most
bacterial IgA protease: Evidence for the presence of enzyme-neutralizing
antibodies in both serum and secretory IgA, and also in serum IgG
(Kobayashi K, Fujiyama Y, Hagiwara K, Kondoh H)
Microbiol.Immunol. 31 : 1097- 1106, 1987.

15) A simple procedure for the isolation of human secretory IgA of IgA1
and IgA2 subclassby a jackfruit lectin, Jacalin, affinity column.
(Kondoh H, Kobayashi K, Hagiwara K)
Molec.Immunol. 24 :1219- 1222. 1987

16) Immunoglobulins of primitive vertebraes.
(Kobayashi K, Tomonaga S, Hagiwara K)
Dev. Comp. Immunol. 12:414- 415, 1988.

17) Jacalin: isolation, characterization and influence of various factors
on its interaction with human IgA1, as assessed by precipitation and
latex agglutination.
(Hagiwara K, Collet-Cassart D, Kobayashi K, Vaerman J-P)

18) Jacalin: Chaos in its immunoglobulin-binding specificity.
(Kobayashi K, Kondoh H, Hagiwara K, Vaerman J-P)
Molec. Immunol. 25 :1037- 1038, 1988.

19) Structural and functional variability of Jacalin.
(Pineu N, Aucouturier P, Preud'homme JL, Hagiwara K, Kobayashi K)
Molec. Immunol. 28:185- 187, 1991.

20) Involvement of the white matter in the initial stage of herpes
simplex encephalitis.
(Ichiyama T, Hayashi T, Yamaguchi E, Tanaka H, Hagiwara K)
Pediatric Radiology 22 :145, 1992

21) Isolation of human herpes virus 6 in an infant with Kawasaki
disease.
(Hagiwara K, Komura H, Kishi F, Kajii T, Yoshida T)
Eur. J. Pediatr. 151: 867- 868, 1992.

22) Terai I, Kobayashi K, Fujita T, Hagiwara K: Human serum
mannose binding protein (MBP): Development of an enzyme-linked
Immunosorbent assay(ELISA) and determination of levels in
serum from 1085 normal Japanese and in some body fluids.
Biochemical Medicine and Metabolic Biology 50:111-119, 1993.

23) Hagiwara K, Ouchi K, Tashiro N, Azuma M, Kobayashi K;
An epidemic of a pertussis-like illness caused by Chlamydia
pneumoniae.

(Books)
1) Separation of human sIgA1 and sIgA2 by affinity chromatography
on the jackfruit lectin, Jacalin.
(Kobayashi K, Hagiwara K, Kondh H, Vaerman J-P) .
In Recent Advances in Mucosal Immunology.
Ed. Mestecky J., McGhee JR. Bienenstock J. & Ogra PL
Plenum Publishing Corporation: New York pp1193-97. 1987.

2) IgA protease from Clostridium Ramosum that cleaves IgA1 and IgA2,
2m(1): The site of cleavageand digestion of secretory IgA.
(Kobayashi k, Fujiyama Y, Hagiwara K, Hodohara K,Hosoda S)
In Recent Advances in Mucosal Immunology. Ed. Mestecky J.,
McGhee JR.,Bienenstock J. & Ogra PL.
Plenum Publishing Corporation: New York pp1289-1296. 1987.

3) Application of the quantitative latex agglutination assay to study
glycoprotein-lectin interaction.
(Hagiwara K, Collet-Cassart D, Vaerman J-P, Masson PL)
In, Lectins: Biology, Biochemistry, Clinical Biochemistry.
Vol. 6: 505- 511. Sigma Chem Co., St Louis, Missouri, U.S.A.1988.

4) A worldwide survey of IgA1-binding lectin, Jacalin, a lectin from
genus Artocarpus.
(Hagiwara K, Kobayashi K)
In, Tsuchiya M et al eds. Frontier of Mucosal Immunology
Vol.1.pp205-208. Elsevier Science Publishers B.V. Amsterdam, 1991.

(Proceedings)
Immunoglobulin of the Hagfish: Molecular structure and evolution.
(Kobayashi K, Tomonaga S, Hagiwara K)In Uyeno T, Arai R, Taniguchi T,
Matsuura K, eds.Proceedings of the Second International Conference on
Indo-Pacific Fishes.The Ichthyological Society of Japan. pp922. 1986.

-------------------------------------------------------------

Grants:
1) 1981. a grant-In-Aid for Scientific Research for the Ministry
of Education, Science & Culture of Japan
(Study on protein synthesis of Molar Trophoblasts)

2) 1984. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Study on action of IgA protease from intestinal bacteria on secretory IgA)
3) 1985. a grant-In-Aid from Naito Memorial Medical Foundation with
Kobayashi K. (A separation procedure of parental secretory IgA by a lectin
and development of a method for elimination of IgA in human gamma-
globulin)

4) 1986. a grant-In-Aid from MORINAGA MILK Co. LTD.
with Kobayashi K. (Studies of anti-protease activity of pathogenic
bacterias present in human sIgA and serum IgA, IgG)

5) 1987. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Biological roles of IgA protease-neutralizing antibody in mucosal defences)

6) 1989. a grant-In-Aid for Scientific Research for the Ministry of Education,
Science & Culture of Japan.
(Anti-bacterial antibody activity of IgA subclass in normal subjects)
http://kaken.nii.ac.jp/en/p/63570440/1989/6/en
7) 1990. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A survey of acute neurological diseases in childhood in Yamaguchi
Prefecture)
8) 1991. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children)
9) 1992. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations, the Ministry of Health &Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children).
(A survey of familial transmission of whooping cough in Yamaguchi
Prefecture) .
(A survey of mother's knowledge of Measles and Measles Vaccine)

10) 1997-8. a grant-In-Aid for Scientific Research for the Ministry of
Education, Science & Culture of Japan.
(Study on rapid diagnosis of sepsis in childhood by PCR method)
平成9年度−10年度 文部省科学研究(一般研究C,500万)
 研究課題:敗血症の迅速診断に関する研究.
 研究代表者:萩原啓二
 分担者:山口医療技術短期大学部(塚原正人,山城安啓)
http://kaken.nii.ac.jp/en/r/50127776
------------------------------------------------------------------------------------------

26 December, 2008

Access & Direction


View Larger Map
near Ube Senior High School

Search by google Map; Type in Japanese < 山口県宇部市常盤台1丁目20-2 >

From the Faculty of Engineering, Yamaguchi University.
➞ down the load to West about 700m & Turn to the Right at the First Signal 200m.


25 December, 2008

Thermometer (old & new)

It was often a troublesome thing to measure the body 
temperature of children. It took 10~15 minutes in old one.  
Thanks to the advance of microelectronics.  Now it take 
few minutes.

This is a Ear thermometer(OMRON). To measure the 
body temperature, just inserting the ear canal.  
This device can measure the temperature of tympanic 
membrane, using the refraction of infra-red beam.  
But not for suitable in child, since the ear canal of children 
is narrow and often difficult in infants.

Any question: write to keiji Hagiwara, M.D.
                                         keijihagiwara@gamil.com

21 December, 2008

What is croup (2) ?


http://www.youtube.com/watch?v=uJ5j4ivnPpc&feature=related

Listen to boy's voice(hoarseness) and strior (coarse musical
sound in breathing). He suffer from " Croup", not the Bronchial
Asthma.


Keiji Hagiwara, M.D.
keijihagiwara@gmail.com

What is Croup (1) ?

            http://fr.youtube.com/watch?v=jTCKpAalkww&feature=related
            Listen her breathing.  hoarse voice is not clear in this video.
          This is not the Bronchial Asthma.
-----------
Croup
----------
Age:        Infant and toddler,  few above 7~10 year old.
Season:   Winter
Etiology:  Virus attack the vocal cord and bronchi
                   (voice box and wind pipe) result the swelling 
                   of it , and airway become  narrow.      

Symptoms:    see and listen above You Tube.
              1) start with slight cough and hoarse voice.
                   and at night suddenly occur the barking cough 
                   , stridor(coarse musical sound in breathing) .
              2) worsening in the night~ mid night and 
                   resolved in noon.  Again worsen at night.
              3) Usually lasts 4~6 days

             ➞     If child seems to be struggling to get a breath
                       go to Emergency medical services immediately !
            
              ☆    Acute epiglottitis due to Haemophlilus influenzae
                       is similar symptoms, but rapidly progress. 
                       Very few in Japan.

Care in home:
           1)  Upright position and using vaporizer in your child room.
           2)  If barking cough and stridor are worsening in 
                the middle of the night, go to Bathroom while 
                the shower on.
           3) Steam almost always works. If it does not, 
                take your child outdoors for a few minutes. 
                Inhaling moist, cool night air may help open the air 
                passages so that she can breathe more freely. 
                If that does not help, call your pediatrician.
                               ----------  American Academy of Pediatrics

Keiji Hagiwara, MD
Kami-Ube Pediatric Clinic
keijihagiwara@gmail.com                

13 December, 2008

Christmas lighting





I have attached the Christmas decoration lights to the 
windows in my clinic.  The light bulbs are made from
LED(Light Emitting Diode), which more powerful lighting
than those of conventional light bulbs.

22 November, 2008

Whooping cough (=Pertussis )

 see →  http://fr.youtube.com/watch?v=dZ5jf-5MobE&feature=related

--------------------------------------
--------------------------------------
❑  What is whooping cough ?
      see   the video clip of  You Tube
      If the infant who received 1or 2 doses of DTaP vaccine, 
      the symptoms such as paroxysmal coughing and 
      inspiratory whoop are not typical.  

❑ Age at risk :  Infant(one-year old or below) 
❑ Etiology:  Gram-negative Bacillus, Bordetella pertussis
❑ Transmission route:  human to human, air droplets
❑ incubation periods:  6~20 days

Any questions:   write to Keiji Hagiwara MD
                                     keijihagiwara@gmail.com