20 October, 2008

BCG vaccine

BCG vaccine in Japan
In 1967, the injection method of Bacillus Calmette et Guérin(BCG 
vaccine was changed from intradermal injection into 18-needles
-press method in Japan.  I don't know the real reason. Probably, 
this method is remained less skin scars at injection site.

----------------------------------Photo:   brown ampule contain Freezed dry BCG vaccine,  
---------------------------------------------Right; 9-needles device.

BCG vaccine was originally produced by French researchers, 
Drs. Calmette and Guérin in Pasteur institute. They attenuated 
Mycobacterium bovis by sequential passage of cultures.

In 1934, Dr. Kiyoshi Shiga (http://en.wikipedia.org/wiki/Kiyoshi_Shiga
, the discoverer of shigella, the bacilluscausing dysentery )
 introduced this strain into Japan.

The side effect of Japan made-BCG vaccine(Tokyo 172 strain), 
such as subaxillary lymph node's swelling , is very few.
---------------------------------One month after BCG injection.  
---------------------------------Note the small abscesses at inoculation sites. 

Any questions:  write to  keijihagiwara@gmail.com
--------------------------------Keiji Hagiwara, MD.
--------------------------------Kami-Ube Pediatric Clinic