which produce penicillins.
(Microbe Library; American Society for Microbiology)
(Microbe Library; American Society for Microbiology)
In 1928, Dr Alexander Fleming accidentally discovered that around green
mold, the staphylococcal colonies are dissolved. He named unidentified
substance , which killed staphylococcus, as penicillin. But Dr. Fleming did
not continued the study of penicillin.
picked up the penicillin and to extract, purified of it. In 1940, they
succeeded the cure of infected mouse by penicillin. and next year,
done the first clinical trials of penicillin in human infection.
The mold which produce penicillins belong to penicillium notatum.
The extraction of penicillins were difficult works, because the
productivity of penicillins by mold were vary in culture media and
conditions and very unstable small molecules(its molecular weights
is from 310 to 350).
Any questions ? write to Keiji Hagiwara, MD
Kami-Ube Pediatric Clinic
keijihagiwara@gmail.com