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Grants:
1) 1981. a grant-In-Aid for Scientific Research for the Ministry
of Education, Science & Culture of Japan
(Study on protein synthesis of Molar Trophoblasts)
2) 1984. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Study on action of IgA protease from intestinal bacteria on secretory IgA)
3) 1985. a grant-In-Aid from Naito Memorial Medical Foundation with
Kobayashi K. (A separation procedure of parental secretory IgA by a lectin
and development of a method for elimination of IgA in human gamma-
globulin)
4) 1986. a grant-In-Aid from MORINAGA MILK Co. LTD.
with Kobayashi K. (Studies of anti-protease activity of pathogenic
bacterias present in human sIgA and serum IgA, IgG)
5) 1987. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Biological roles of IgA protease-neutralizing antibody in mucosal defences)
6) 1989. a grant-In-Aid for Scientific Research for the Ministry of Education,
Science & Culture of Japan.
(Anti-bacterial antibody activity of IgA subclass in normal subjects)
→ http://kaken.nii.ac.jp/en/p/63570440/1989/6/en
7) 1990. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A survey of acute neurological diseases in childhood in Yamaguchi
Prefecture)
8) 1991. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children)
9) 1992. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations, the Ministry of Health &Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children).
(A survey of familial transmission of whooping cough in Yamaguchi
Prefecture) .
(A survey of mother's knowledge of Measles and Measles Vaccine)
10) 1997-8. a grant-In-Aid for Scientific Research for the Ministry of
Education, Science & Culture of Japan.
(Study on rapid diagnosis of sepsis in childhood by PCR method)
平成９年度−10年度 文部省科学研究（一般研究C，５００万)
研究課題：敗血症の迅速診断に関する研究.
研究代表者：萩原啓二
分担者：山口医療技術短期大学部（塚原正人，山城安啓）
→ http://kaken.nii.ac.jp/en/r/50127776
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Publications:
Omit the Japanese publication.
(Journal)
1) Monozygotic twins discordant for Rubinstein-Taybi syndrome.
(Kajii T, Hagiwara K, Tsukahara M, Nakajima H, Fukuda Y)
2) Dispermic origin of XY hydatidiform moles. (Ohama K, kajii T, Okamoto E, Fukuda Y, Imaizumi K, Tsukahara M,
Kobayashi K, Hagiwara K,)
3) Esterase D polymorphism in hydatidiform mole. (Hagiwara K, Kobayashi K, Kajii T)
Jpn. J. Hum. Genet. 27(2)180,1982.
4) Pfeiffer syndrome or Saethre-Chotzen syndrome? (Tsukahara M, Hagiwara K, Kajii T)
5) J chain -like component in 18-S immunoglobulin of the skate,
Raja kenojei, a cartilaginous fish.
(Hagiwara K, Kobayashi K, Kajii T, Tomonaga S)
Molec. Immunol. 22 :775- 778, 1985.(July)
6) Isolation and characterization of immunoglobulin of hagfish,
Eptatretus burgeri, a primitive vertebrae.
(Kobayashi K, Tomonaga S, Hagiwara K)
Molec. Immunol. 22 : 1091- 1097, 1985.(Sep)
7) Studies of immunoglobulin and immunoglobulin-forming cells in Heterodontus japonics, a cartilaginous fish.
(Tomonaga S, Kobayashi K, Hagiwara K, Sasaki K, Sezaki K)
Devel. Comparat .Immunol. 9 : 617- 626, 1985.
8) Purification and characterization of esterase D1 and D2 from human
erythrocytes: Evidence that they are monomers.
( Matsuo K, Kobayashi K, Hagiwara K, Kajii T)
Eur. J. Biochem. 153 : 217-222, 1985.
9) Double precipitin arcs of IgA myeloma sera on immuno-electrophoresis: Origin and suggestion of IgA2,2m(2) allotype.
(Kobayashi K, Hagiwara K, Vaerman J-P, Kajii T)
Immunol. Invest. 14 :455- 468, 1985.
10) Serum proteins in vesicular fluid of hydatidiform moles: A lack of
selectivity of molar trophoblast in the transfer of maternal serum proteins.
(Hagiwara K, Kobayashi K, Kajii T)
11) Gut-associated lymphoid tissue in Elasmobranchs. (Tomonaga S, Kobayashi K, Hagiwara K, Yamaguchi K,Awaya K)
Zool. Sci. 3 :453- 458, 1986.
12) Jacalin, a jackfruit lectin, precipitate IgA1 but not IgA2 subclass on
gel diffusion reaction.
(Kondoh H, Kobayashi K, Hagiwara K, Kajii T)
13) Complexes of albumin and a1-antitrypsin with Fc fragment of IgA
monomer are disulfide bond to penultimate C-terminal cysteine in
the Ca3 domain.
(Vaerman J-P, Hagiwara K, Kobayashi K, Rits M)
Immunol. Letters 15: 67- 72, 1987.
14) Normal serum IgA as well as secretory IgA is resistance to most bacterial IgA protease: Evidence for the presence of enzyme-neutralizing
antibodies in both serum and secretory IgA, and also in serum IgG
(Kobayashi K, Fujiyama Y, Hagiwara K, Kondoh H)
Microbiol.Immunol. 31 : 1097- 1106, 1987.
15) A simple procedure for the isolation of human secretory IgA of IgA1 and IgA2 subclassby a jackfruit lectin, Jacalin, affinity column.
(Kondoh H, Kobayashi K, Hagiwara K)
Molec.Immunol. 24 :1219- 1222. 1987
16) Immunoglobulins of primitive vertebraes.
(Kobayashi K, Tomonaga S, Hagiwara K)
Dev. Comp. Immunol. 12:414- 415, 1988.
17) Jacalin: isolation, characterization and influence of various factors on its interaction with human IgA1, as assessed by precipitation and
latex agglutination.
(Hagiwara K, Collet-Cassart D, Kobayashi K, Vaerman J-P)
18) Jacalin: Chaos in its immunoglobulin-binding specificity.
(Kobayashi K, Kondoh H, Hagiwara K, Vaerman J-P)
Molec. Immunol. 25 :1037- 1038, 1988.
19) Structural and functional variability of Jacalin.
(Pineu N, Aucouturier P, Preud'homme JL, Hagiwara K, Kobayashi K)
Molec. Immunol. 28:185- 187, 1991.
20) Involvement of the white matter in the initial stage of herpes
simplex encephalitis.
(Ichiyama T, Hayashi T, Yamaguchi E, Tanaka H, Hagiwara K)
Pediatric Radiology 22 :145, 1992
21) Isolation of human herpes virus 6 in an infant with Kawasaki disease.
(Hagiwara K, Komura H, Kishi F, Kajii T, Yoshida T)
Eur. J. Pediatr. 151: 867- 868, 1992.
22) Terai I, Kobayashi K, Fujita T, Hagiwara K: Human serum mannose binding protein (MBP): Development of an enzyme-linked
Immunosorbent assay(ELISA) and determination of levels in
serum from 1085 normal Japanese and in some body fluids.
Biochemical Medicine and Metabolic Biology 50:111-119, 1993.
23) Hagiwara K, Ouchi K, Tashiro N, Azuma M, Kobayashi K; An epidemic of a pertussis-like illness caused by Chlamydia
pneumoniae.
(Books)
1) Separation of human sIgA1 and sIgA2 by affinity chromatography
on the jackfruit lectin, Jacalin.
(Kobayashi K, Hagiwara K, Kondh H, Vaerman J-P) .
In Recent Advances in Mucosal Immunology.
Ed. Mestecky J., McGhee JR. Bienenstock J. & Ogra PL
Plenum Publishing Corporation: New York pp1193-97. 1987.
2) IgA protease from Clostridium Ramosum that cleaves IgA1 and IgA2,
2m(1): The site of cleavageand digestion of secretory IgA.
(Kobayashi k, Fujiyama Y, Hagiwara K, Hodohara K,Hosoda S)
In Recent Advances in Mucosal Immunology. Ed. Mestecky J.,
McGhee JR.,Bienenstock J. & Ogra PL.
Plenum Publishing Corporation: New York pp1289-1296. 1987.
3) Application of the quantitative latex agglutination assay to study
glycoprotein-lectin interaction.
(Hagiwara K, Collet-Cassart D, Vaerman J-P, Masson PL)
In, Lectins: Biology, Biochemistry, Clinical Biochemistry.
Vol. 6: 505- 511. Sigma Chem Co., St Louis, Missouri, U.S.A.1988.
4) A worldwide survey of IgA1-binding lectin, Jacalin, a lectin from
genus Artocarpus. (Hagiwara K, Kobayashi K)
In, Tsuchiya M et al eds. Frontier of Mucosal Immunology
Vol.1.pp205-208. Elsevier Science Publishers B.V. Amsterdam, 1991.
(Proceedings) Immunoglobulin of the Hagfish: Molecular structure and evolution.
(Kobayashi K, Tomonaga S, Hagiwara K)In Uyeno T, Arai R, Taniguchi T,
Matsuura K, eds.Proceedings of the Second International Conference on
Indo-Pacific Fishes.The Ichthyological Society of Japan. pp922. 1986.
-------------------------------------------------------------
1) 1981. a grant-In-Aid for Scientific Research for the Ministry
of Education, Science & Culture of Japan
(Study on protein synthesis of Molar Trophoblasts)
2) 1984. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Study on action of IgA protease from intestinal bacteria on secretory IgA)
3) 1985. a grant-In-Aid from Naito Memorial Medical Foundation with
Kobayashi K. (A separation procedure of parental secretory IgA by a lectin
and development of a method for elimination of IgA in human gamma-
globulin)
4) 1986. a grant-In-Aid from MORINAGA MILK Co. LTD.
with Kobayashi K. (Studies of anti-protease activity of pathogenic
bacterias present in human sIgA and serum IgA, IgG)
5) 1987. a grant-In-Aid from MORINAGA MILK Co. LTD.
(Biological roles of IgA protease-neutralizing antibody in mucosal defences)
6) 1989. a grant-In-Aid for Scientific Research for the Ministry of Education,
Science & Culture of Japan.
(Anti-bacterial antibody activity of IgA subclass in normal subjects)
→ http://kaken.nii.ac.jp/en/p/63570440/1989/6/en
7) 1990. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A survey of acute neurological diseases in childhood in Yamaguchi
Prefecture)
8) 1991. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations , the Ministry of Health & Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children)
9) 1992. a grant-In-Aid from Research Project for Adverse Effect of
Immunizations, the Ministry of Health &Welfare of Japan.
(A follow-up study of varicella's vaccinees in healthy children).
(A survey of familial transmission of whooping cough in Yamaguchi
Prefecture) .
(A survey of mother's knowledge of Measles and Measles Vaccine)
10) 1997-8. a grant-In-Aid for Scientific Research for the Ministry of
Education, Science & Culture of Japan.
(Study on rapid diagnosis of sepsis in childhood by PCR method)
平成９年度−10年度 文部省科学研究（一般研究C，５００万)
研究課題：敗血症の迅速診断に関する研究.
研究代表者：萩原啓二
分担者：山口医療技術短期大学部（塚原正人，山城安啓）
→ http://kaken.nii.ac.jp/en/r/50127776
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||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||Fig : a fever chart of Roseola(1-year-old infant).
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